Kirksville has a powerful reputation for meth, as does the entire state of Missouri, which has the highest rate of meth lab activity in the United States. Yet, despite the culture that rages outside of the University, the campus is pretty much drug-free. There are a couple of fraternities inextricably linked with marijuana and some mildly harder drugs, but you won't find any visible drug use unless you go looking. There have been no rumors of ecstasy or GHB use among students.
On the other hand, almost everyone knows someone who has been busted for pot, usually because that person was dumb enough to try to smoke it in a residence hall. Just like with alcohol use, if you are smart enough to control your impulses, you won't get caught. Punishment can be harsh if you hear a DPS officer knock on your door. Students at Truman are definitely not pressured to use drugs. In fact, well-meaning friends are more often encouraging their peers to stop drinking and smoking.