The neighborhood around Regis is sort of sketchy, but the University has a kind of bubble around it. When you walk past the fence that surrounds Regis, you feel safe and secure. Campus Security is always wandering around at night, and they are glad to help you with anything you need. Generally, there is not a lot of crime on the Regis campus; as long as you're not mindless with walking around the surrounding neighborhoods, you'll be fine.
Campus Security is there for students 24/7, so if you don't feel safe walking through campus at night, call them and they will be happy to escort you. The neighborhood around Regis is fine to walk through in daylight, but maybe have a friend pick you up or drive you to a friend's house at night. Also, the school has safety boxes stationed around campus that connect directly to Campus Security.